Currently, the only available antibody-based test for mutant BRAF protein uses the monoclonal antibody VE1 to detect expression in tumor samples using IHC.26, 90, 91 This approach is effective in identifying a qualitative change (ie, presence or absence of the protein) but is less accurate in quantitating changes in expression than other antibody-based assays, such as the enzyme-linked immunosorbent assay.92 The gene discussed is BRAF; the disease is neoplasm.