The quantity of BRAF V600E mutation-specific DNA has been shown to be positively correlated to tumor burden and disease stage.78, 79, 80 Accordingly, patients with BRAF-positive ctDNA had significantly shorter progression-free and overall survival than patients without detectable BRAF-positive ctDNA.78 The quantity of BRAF V600E-positive ctDNA was also shown to be greater in patients with more metastatic sites.81 Here, BRAF is linked to neoplasm.