In addition, these MR single nucleotide polymorphisms (SNPs) together result in four haplotypes (GA, CA, CG, GG).The common and functional CA haplotype, which results in higher transcriptional, translational and transactivational MR activity, has been associated with enhanced resilience to depression (Klok et al., 2011) as well as traumatic stress (ter Heegde et al., 2015; de Kloet et al., 2016). The gene discussed is NR3C2; the disease is major depressive disorder.