FOXO3 and urinary bladder cancer: For further discussion, it is reported that the overexpression of Thromboxane-A2 isoform-β receptor (TPβ) plays an important role in the process of human bladder cancer, and TP agonist decreased acetylation of FOXO3 via upregulation of SIRT1 in the bladder cancer cell line UMUC3 [60].