CCNE1 and hepatocellular carcinoma: Knockdown of CDR1AS promoted the expression of miR-7 and suppressed its targets, CCNE1 (cyclin E1) and PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta): this molecular cascade resulted in a reduction of cell proliferation and invasion in HCC [151].