Interestingly, other authors found very similar findings in ESCC: cir-ITCH worked as a miRNA sponge for miR-7, miR-17, and miR-214, increased ITCH expression, and promoted ubiquitin-mediated DVL2 degradation, thus inhibiting canonical Wnt signaling [150]. The gene discussed is ITCH; the disease is esophageal squamous cell carcinoma.