The results of the present study demonstrated the following: (i) persistent organ failure and early hypoalbuminemia occurred in 9.7% and 39.3% of patients with acute pancreatitis, respectively; (ii) as a risk factor, low serum albumin levels within 24 hours of admission are independently associated with the development of persistent organ failure and mortality in acute pancreatitis. The gene discussed is ALB; the disease is Hypoalbuminemia.