CFH and age-related macular degeneration: In fact, in the Unites States, the Y402H (rs1061170) variant within the complement factor H (CFH) gene and the A69S (rs10490924) variant within the age-related maculopathy susceptibility 2 (ARMS2) locus increased the risk (1.5- to 3-fold) for both early-stage and late-stage AMD in individuals of European ancestry [116, 117].