VEGFA and nasopharyngeal carcinoma: Because the predominant pattern of failure in loco-regionally advanced NPC is distant metastasis and because patients with increased VEGF have a higher likelihood of recurrence, distant metastases, and decreased survival, Lee and coworkers did a phase 2 multi-institutional trial (RTOG 0615) to test the addition of bevacizumab (a monoclonal antibody directed against VEGF) to standard chemoradiation treatment for this group of patients.