Huang et al found that there were inverse correlations between the expression of p16, nm23-H1, or E-cadherin protein and lymph node metastasis (P < 0.05), indicating that the expressions of p16, nm23-H1, and E-cadherin gene were related to the prognosis of patients with NPC [86]. The gene discussed is CDKN2A; the disease is metastasis.