KRAS and colorectal adenocarcinoma: In theory, the predictive value of the KRAS gene relative to the relapse and prognosis of colorectal adenocarcinoma is most likely associated with highly specific mutations involving nucleotide changes distributed along the codons, which result in the production of different amino acids, persistent protein Ras activity, and the amplification of this signaling pathway, even in the absence of effectors and regulators of extracellular stimulation.