Table 1 shows that the mean difference (before - after) treatment for α1-AT blood levels is highly significant in lung and prostate cancer as indicated by 95% confidence interval (CI) and the P-values. Table 2 and 3 are also demonstrate that the mean difference (before - after) treatment for α1-AT blood levels in lung and prostate cancer patients according to the stage of the disease is highly significant with the widening of the range of difference when we go toward more advanced stages. This evidence concerns the gene SERPINA1 and Familial prostate cancer.