AKT1 and cancer: There are some observations related to the inhibitory effects of natural products against Akt, such as indole-3-carbinol (I3C) [26] and genistein [27], et al. Because of Akt’s major role in the hindrance of apoptosis through multiple mechanisms and its aberrantly activation in many cancers, especially, in more than half of primary carcinoma of bladder [28], the inhibition of the PI3K/Akt signaling pathway has emerged as an effective means to induce apoptosis, implicating an attractive target of chemopreventive agents in bladder cancer prevention and treatment.