There are some observations related to the inhibitory effects of natural products against Akt, such as indole-3-carbinol (I3C) [26] and genistein [27], et al. Because of Akt’s major role in the hindrance of apoptosis through multiple mechanisms and its aberrantly activation in many cancers, especially, in more than half of primary carcinoma of bladder [28], the inhibition of the PI3K/Akt signaling pathway has emerged as an effective means to induce apoptosis, implicating an attractive target of chemopreventive agents in bladder cancer prevention and treatment. Here, AKT1 is linked to urinary bladder cancer.