PTGS2 and cancer: Chemoprevention is regarded as one of the most potent and realistic anti-cancer approaches aimed at decreasing the morbidity and mortality of cancer by induction of various cancer cells apoptosis through regulation of Akt, c-myc, nuclear factor КB (NF-КB), cyclooxygenase-2 (COX-2), apoptotic and other pathways [2-10].