MYC and osteosarcoma: There are reports in contrast to our findings in the literature that apoptosis could be induced through downregulation of c-myc in curcumin-treated Burkitt’s Lymphoma Raji cells [35], osteosarcoma cells [36], bladder cancer 253BJV cells [37], colorectal cancer cells [38], Hodgkin’s Lymphoma cells [39], HTLV-1-infected T-cell [40], and so on.