In our study, we examined the expression of HLA-I, CD8 and CD4 in tissues of cervical cancer, cervical intraepithelial neoplasia (CIN), chronic cervicitis and peri-cancer tissues using SP immunohistochemistry, to understand local immune state of cervix and investigate their association with cervical cancer. This evidence concerns the gene CD8A and cervical intraepithelial neoplasia.