We also found an increased association between the PP variant and involvement of lymph nodes, which might be due to the reason that PP variant might facilitate in stimulating axillary lymph node metastasis, which is in agreement with previously functional studies in the biological consequences of these variations in P53 protein functions [8].To date axillary lymph node status is the best prognostic indicator in breast cancer [25, 26]. The gene discussed is TP53; the disease is breast cancer.