Cytogenetically, SS is characterized by the reciprocal chromosomal translocation t(X;18)(p11.2;q11.2), involving fusion of the SYT gene located on chromosome 18 (18q11) to either the SSX1, the SSX2 or the SSX4 gene located on chromosome X, (Xp11) [22]. The gene discussed is SSX4; the disease is synovial sarcoma.