Over expression of RhoC was found to be correlated with prognosis in patients with pancreatic adenocarcinoma, with enhanced RhoC expression resulting in an increase in migration and invasion of pancreatic carcinoma cells [7, 8], while RhoA and RhoC up-regulation have been shown to be associated with tumor progression in ovarian carcinoma [9]. The gene discussed is RHOC; the disease is pancreatic adenocarcinoma.