This is based on the following: (1) high-resolution imaging demonstrate a close spatial proximity between CXCR3 and LRP1, (2) the complex is co-immunoprecipitated in CXCR3/LRP1 expressing cells, (3) the complex is present not only in tumor cells, but also in non-transformed cells such as smooth muscle cells, which have an important role in vessel maintenance and integrity, (4) the interaction between CXCR3 and LRP1 was inhibited by RAP, and (5) a model could be constructed for the CXCR3-A:LRP1 interaction involving in ECL2 of CXCR3 and CR26 of LRPIV. This evidence concerns the gene LRP1 and neoplasm.