Of note, an early report from Ghobrial et al. 10 aimed to determine chemokine receptors expressed by CLL cells found that CXCR1 and CXCR2 were absent in 45 peripheral blood samples, and more recently Levidou et al. were neither able to detect CXCR2 on lymph node samples from CLL patients11. Here, CXCR2 is linked to B-cell chronic lymphocytic leukemia.