BRCA1 and breast neoplasm: Notably, the calculated BRCA scores using the BRCA1/2-based profile achieved the best classification accuracy when comparing familial breast tumors from sporadic ones (Fig. 2b, right, AUC = 0.861 for BRCA1 vs. sporadic, ACU = 0.809 for BRCA2 vs. sporadic and AUC = 0.84 for BRCA1/2 vs. sporadic).