Similar to our observations in U18666A-treated cells, JIP4 depletion reduced perinuclear clustering of lysosomes in NPC fibroblasts (Fig. 7h, Supplementary Fig. 9f, g), suggesting that alterations in the TMEM55B/JIP4 pathway may contribute to the pathology of the disease. This evidence concerns the gene PIP4P1 and nasopharyngeal carcinoma.