Opposite changes in the same imprinted genomic regions can lead to opposite growth phenotypes, such as growth restriction in SRS and overgrowth in Beckwith-Wiedemann syndrome (BWS), caused by hypo- and hypermethylation, respectively, of the imprinted H19-IGF2 region in 11p15 (H19/IGF2:IG-DMR) in a proportion of the cases3. This evidence concerns the gene IGF2 and Beckwith-Wiedemann syndrome.