A statistically significant increase in percentage of ASC specks (exposed to 3 h LPS followed by 3 h infection), and FLICA (caspase-1 active) and propidium iodide (PI) double-positive (pyroptotic) cells in WT vs. WAS KO BMDCs was also recorded (Fig. 2b, c and Supplementary Fig. 2A). Here, CASP1 is linked to infection.