CRP and cardiovascular disorder: This affords the opportunity to examine: (i) the association of CRP with risk of cardiovascular disease; (ii) the associations, in randomized and observational analyses, of LDL-C with risk of cardiovascular disease; (iii) whether the degree of underlying inflammation modified the strength of the association between LDL-C and cardiovascular risk in this population; and (iv) the separate associations of CRP and of LDL-C with nonvascular outcomes.