LATS2 and esophageal squamous cell carcinoma: In order to address whether LATS2 directly inhibited TAZ and determine the function of LATS2/TAZ in ESCC prognosis, we performed qRT-PCR and western blotting assays and observed that both TAZ mRNA and protein levels were declined and increased respectively, which transfected cDNA/LATS2 and siRNA/LATS2 (Fig. 8a–c).