Therefore, we summarized that TGF-β2 could induced autophagy in glioma via both Smad and non-Smad pathway (JNK pathway), and inhibiting autophagy could also in turn mediated endogenous TGF-β2 level in an autocrine fashion which might resulted from the changing of lactate level secreted by glioma cells. The gene discussed is MAPK8; the disease is central nervous system cancer.