Although DRB1*15 alleles have also been associated to other autoimmune diseases, including the IgG4-mediated anti-PLA2R membranous nephropathy [27], the association of DRB1*15 with three different diseases (multiple sclerosis, multifocal motor neuropathy, and anti-NF155+ CIDP) in which myelinating cells (oligodendrocytes and Schwann cells) are targeted by immune system may suggest convergent pathophysiological mechanisms in which myelin antigen presentation with DRB1*15 HLA class II is central. The gene discussed is PMP22; the disease is multiple sclerosis.