Histopathological and immunohistochemical workup (antibodies listed in Table 2) of the specimen collected via endoscopy yielded the unexpected diagnosis of a partly necrotic, highly differentiated pancreatic tumor, strongly positive for keratin 7 (CK7) and pankeratin AE1/AE3, and alpha 1 antichymotrypsin; negative for synaptophysin and chromogranin A, CDx2, CK20, S100, MUC 2, MUC5AC, carcinoembryonic antigen (CEA), and somatostatin; and in part positive for CA19-9 (20% of cells positive). The gene discussed is KRT7; the disease is pancreatic neoplasm.