HSPA8 and breast carcinoma: Hsp70 overexpression correlates with TNBC metastasis in murine models and human breast cancer patients [24], but knock down of cytosolic Hsc70 (a constitutive Hsp70) or Hsp70 (the inducible Hsp70) in breast cancer lines exhibits distinct responses, probably due to the relative expression levels of the two chaperones [61, 134].