These genes notably included Egr1, Egr2, Egr3, Nr4a1, Nr4a3, Arc, and Sgk1. Since it is known that SD results in elevated levels of OxA in the locus coeruleus and hypothalamus [79], increased hypothalamic OxA immunoreactivity [80,81], and increased expression of c-fos in orexinergic neurons [82], these parallels between the data presented here and gene regulation in SD suggest strongly that the events occurring in OX1-expressing GT1-7 cells are of significant physiological relevance. This evidence concerns the gene EGR2 and Salla disease.