Expression of FCGR1A/B and SERPING1, the inflammasome adaptor ASC/PYCARD and NCF1 (p47phox), which mediates inflammatory signaling in TB [20], were increased in monocytes from progressors who expressed the whole blood signature of risk for TB, compared to controls who did not express the signature of risk (S8 Table, S2A Fig). The gene discussed is PYCARD; the disease is tuberculosis.