This was followed by changes in blood coagulation modules (containing coagulation factor X, fibrinogen, D-dimer, fibrinogen gamma chain, thrombospondin 1, SERPIN A1 and D1, and platelet factor 4) and by myeloid inflammation modules (containing CXCL9, CCL1, CD163, IL-6 and RANTES), which emerged after complement activation, around 200 days before TB diagnosis. The gene discussed is THBS1; the disease is tuberculosis.