STIM1 and heart failure: On the other hand, Correll et al. showed that transgenic mice with STIM1 overexpression exhibited sudden cardiac death as early as 6 weeks of age, while mice surviving past 12 weeks of age developed heart failure with hypertrophy, induction of the fetal gene program, histopathology and mitochondrial structural alterations, loss of ventricular functional performance and pulmonary edema [33].