Therefore, a systematic review and meta-analysis has been carried out to explore the expression of these 3 well-known lncRNAs (TUG1, SPRY4-IT1, and HULC) and lymph node metastasis and the overall survival to prove these 3 lncRNAS might serve as biomarkers in cancer prognosis and diagnosis. The gene discussed is SPRY4; the disease is cancer.