In conclusion, this meta-analysis provides evidences that expressions of 3 lncRNAs (TUG1, SPRY4-IT1, and HULC) are significantly associated with overall survival in cancer patients, which means that these 3 lncRNAs may have great potential to be an accurate biomarker to reveal the value of diagnosis and prognosis in diverse cancers. The gene discussed is SPRY4; the disease is cancer.