IL1A and hepatocellular carcinoma: Previous studies have shown the rs3783553 can alter the binding of both miR-122 and miR-378 in hepatocellular carcinoma and gastric cancer cell lines.[16,29] In this study, we constructed plasmids to examine whether the polymorphism can affect the binding of miR-122 and miR-378 with the 3’UTR of IL-1A in HEK293 cells.