The decreased risk was also observed in endometriosis.[21,22] Moreover, the decreased-risk genotype was reported to relate to an increasing body mass index, decreasing HDL-C, and low level of serum IL-1α in Egyptian patients with nonalcoholic fatty liver disease.[26] Yang et al[24] reported that the rs3783553 TTCA del allele was associated with an elevated risk for osteoarthritis and disease severity. This evidence concerns the gene IL1A and osteoarthritis.