GRP and neoplasm: And high expression of NSE (P = .008), high level of LDH > 200 IU/L (P = .027), stage ED (P = .008), distant metastasis (P = .025), and chemotherapy cycles≤4 (P = .034) were factors in predicting worse PFS, while ProGRP (P = .526), age (P = .526), gender (P = .649), smoking history (P = .151), and tumor size (P = .240) were not correlated with PFS (Table 5).