ENO2 and small cell lung carcinoma: Previous studies have already presented that NSE has a potential role of mirroring the SCLC disease activity and metabolism, and then was applied to early predict insufficient response to chemotherapy.[5,6,14,15,18] As one of the most powerful prognostic markers for SCLC, NSE has been widely and preferentially used in clinical trial and routine practice.[5,18,19]