REN and Hypertension resistant to conventional therapy: In the case of single-nucleotide polymorphisms that do not affect the PY motif, the full Liddle’s phenotype is not usually present.5,6 A variant (R563Q, c.1815G>A) of the beta-subunit of the epithelial sodium channel was found frequently in patients with resistant hypertension and with low renin and aldosterone levels.7 This variant was described to result in the full Liddle’s phenotype during pregnancy;8 and in black South African hypertensive patients, the prevalence was 5.9% versus 1.7% in normotensives.1