In this study, we first revealed that AR differentially regulated circRNA expression in HCC through ADAR1 that could directly suppress RNA circularization.19 Moreover, we found AR influenced expression of circRNAs significantly among those originated from polyadenylate-binding protein 1 gene (PABPC1) and indeed one of them, hsa_circ_0085154, could regulate HCC proliferation in vivo. This evidence concerns the gene PABPC1 and hepatocellular carcinoma.