Our work revealed that FMRP is overexpressed in melanoma cells with respect to normal melanocytes (Figures 1 and 2) and its expression significantly correlates with two main prognostic factors of melanoma cancer progression: Breslow thickness (how deeply tumor cells have invaded) and Clark level (level of anatomical invasion of the melanoma in the skin); furthermore, the analysis of FMR1 expression levels in the cohort included in the melanoma TCGA skin cutaneous melanoma indicates that FMRP expression correlates with the risk of tumor relapse and disease-free survival (Figure 1). This evidence concerns the gene FMR1 and neoplasm.