FMRP expression was analyzed by IHC with a specific FMRP antibody,29 in a panel of formalin-fixed paraffin-embedded tumor tissues (N=64) classified into four main subtypes: lentigo maligna melanoma (LMM), superficial spreading melanoma (SSM), acral lentiginous melanoma (ALM) and nodular melanoma (NM), the only histotype showing vertical growth phase ab initio. The gene discussed is FMR1; the disease is superficial spreading melanoma.