FMR1 and melanoma: To verify whether lack of FMRP might lead to different capacity of melanoma cells to migrate, invade and/or adhere, we knocked down FMRP expression in 501 mel (Supplementary Figure 1a) or A375 cells (Supplementary Figure 1b), treating the cells for 24, 48 or 72 h with a scrambled or specific small interfering RNAs (siRNAs) (FMR1 siRNA).