FMRP has been largely studied in the brain,43 where it has an important role in the local regulation of mRNA metabolism, and only recently in breast cancer.18 Despite the fact that neurons, breast cancer cells and melanoma cells share a number of similarities in their gene expression pattern,44, 45, 46 signaling pathways (including PKC- and p53/p73-dependent pathways) and signaling molecules (such as Wnt, fibroblast growth factors and neurotrophins),44 FMRP function/s in melanocytic cells or in their tumoral counterpart has never been investigated. Here, FMR1 is linked to melanoma.