Of note, using an NGS transcriptome approach, we identified a wide panel of mRNAs with altered levels in the absence of FMRP (named FRGs) (Figure 7a and Supplementary Table 1) that confirms a role for FMRP in regulating (directly or indirectly) processes that occur in the peripheral part of the cells and that contribute to the modulation of the cytoskeletal and morphological plasticity at the leading edges of cancer cells during migration and invasion (Figures 7c and d). The gene discussed is FMR1; the disease is cancer.