FMR1 and melanoma: FMRP expression was also analyzed by semiquantitative western blotting of 12 melanoma cell lines derived from patients with invasive and metastatic melanomas (MM), upon being shortly cultured (melanoma short-term cultures).30 The overall expression of FMRP was significantly increased in melanoma cells compared with normal human epidermal melanocytes (NHEMs) (Figure 2a).