We further investigated the expression of FMRP in two metastatic melanoma cell lines, the pigmented 501 mel31 and the unpigmented A375.32, 33 The 501 mel cell line exhibited higher FMRP levels compared with control adult human epidermal melanocytes (HEM-Ad) and neonatal NHEMs (NHEM-neo) (Figure 2c). The gene discussed is FMR1; the disease is melanoma.