SELPLG and anterior ischemic optic neuropathy: This finding is consistent with previous reports that BONB stabilization can reduce inflammation and macrophage migration in ON tissue.32 Furthermore, we demonstrated that P-sel-IgG exerts neuroprotection via the Nrf2 signaling pathway, consistent with a previous study that used a similar kind of PSGL-1 recombinant protein.27 In addition, Nrf2 activation is protective in intracerebral hemorrhage33 and middle cerebral artery occlusion in the brain,34 which are also CNS disorders, along with AION.