This finding is consistent with previous reports that BONB stabilization can reduce inflammation and macrophage migration in ON tissue.32 Furthermore, we demonstrated that P-sel-IgG exerts neuroprotection via the Nrf2 signaling pathway, consistent with a previous study that used a similar kind of PSGL-1 recombinant protein.27 In addition, Nrf2 activation is protective in intracerebral hemorrhage33 and middle cerebral artery occlusion in the brain,34 which are also CNS disorders, along with AION. This evidence concerns the gene SELPLG and central nervous system disorder.