F2RL1 and neuropathic pain: For example, activation of bradykinin receptors (B1 and B2) [22,23], prostaglandin E2 (PGE2) receptors (EP1 and EP4) [24], histamine receptors (H1 and H2) [25], purinergic receptors (P2Y) [26], protease-activated receptor 2 (PAR2) [27], and various chemokine receptors [28] by their respective ligands have been shown to influence activation kinetics of nociceptors and contribute to long-term sensitisation associated with neuropathic pain.