For example, the combination of gemcitabine and a polymeric encapsulated NP formulation polymeric nanoparticle-encapsulated curcumin (NanoCurc) was shown to enhance tumor growth inhibition, abolish systemic metastases and reduce activation of NF-κB in a pancreatic cancer mouse xenograft model, compared to either agent alone [142]. This evidence concerns the gene NFKB1 and pancreatic neoplasm.