Signaling pathways regulating growth, proliferation, differentiation, apoptosis, invasion and angiogenesis, such as Akt, epidermal growth factor receptor (EGFR), Notch, mitogen-activated protein kinases (MAPK), nuclear factor (NF)-κB and Sonic Hedgehog (SHH) pathways, appear to, directly or indirectly, impact pancreatic tumor chemosensitivity. Here, EGFR is linked to pancreatic neoplasm.