Recently, it has been reported that in the PDAC microenvironment, PSCs are a source of the matricellular cysteine-rich angiogenic inducer 61 (CYR61) protein, which in co-culture models with pancreatic cancer cell lines induces chemoresistance in tumor cells by downregulating NTs [83]. The gene discussed is CCN1; the disease is familial pancreatic carcinoma.