VEGFA and neoplasm: The combination of an anti-cotinine antibody (cot-body) with a cotinine labeled vascular endothelial growth factor (VEGF) targeting aptamer (cot-pega) led to the formation of an oligobody that exhibited no loss in affinity to cancer cells compared to the aptamer only, penetrated deep into tumor tissue of an A549-xenograft mouse model, displayed extended half-life times in serum (t1/2 = 8.3 h) and reduced tumor growth.