To exclude the possibility that the atherosclerotic phenotype was secondary to changes in lipid metabolism and to explore the degree to which atherosclerosis was driven by Lrp1 tyrosine phosphorylation in macrophages, we performed bone marrow transplants where Ldlr−/− or Lrp1Y63F;Ldlr−/− bone-marrow was transplanted into irradiated Ldlr−/− mice. Here, LDLR is linked to atherosclerosis.