In accordance to that, the stimulation of the Nrf2 transcription factor, principal inductor of HO-1 synthesis, also inhibited neuropathy in type 1 and 2 diabetic animals [13,20], showing that the Nrf2/HO-1 signaling pathway activation plays a key role alleviating the nociceptive behaviors linked to diabetes. This evidence concerns the gene HMOX1 and neuropathy.