MAPK (JNK, ERK and p38) are also implicated in the modulation of diabetic neuropathy [14,36], so activated MAPK were demonstrated in the dorsal root ganglia and/or sciatic nerve of db/db mice and its inhibition attenuated pain sensitivity displayed in these animals at the early phase of diabetes [15,16,20]. The gene discussed is MAPK8; the disease is diabetes mellitus.