Therefore, in BKS.Cg-m+/+Leprdb/J (db/db) male mice which develop type 2 diabetes, with mechanical allodynia, hyperglycemia and obesity from 6-12 weeks of age [20,24,25], we investigated whether treatment with CoPP attenuated them through regulating the Nrf2, HO-1, NQO1 and JNK protein levels in the sciatic nerve of these animals. This evidence concerns the gene HMOX1 and obesity due to melanocortin 4 receptor deficiency.