Strengths of this review include evaluation of a comprehensive evidence base, use of a pre-specified protocol incorporating numerous major scientific databases, and assessment of additional areas relevant to HBsAg diagnostic testing, notably comparison with NAT and potential impact of occult hepatitis B. We identified 11 additional articles [18, 22, 25, 28, 29, 35, 37, 43, 45–47] not found in the most recent systematic review assessing the diagnostic accuracy of RDTs [11]. Here, BRD2 is linked to hepatitis B virus infection.