The risk of developing colorectal cancer (CRC) in about 4654 patients was assessed by Hughes et al. [66] using the Weisenberg panel of genes to define the CpG Island Methylator Phenotype (CIMP) tumors (calcium voltage-gated channel subunit alpha1 G, CACNA1G; insulin like growth factor 2, IGF2; neurogenin 1, NEUROG1; runt related transcription factor 3, RUNX3; suppressor of cytokine signaling 1, SOCS1) and examined the associations between BMI, waist circumference and self-reported PA level and CRC risk. The gene discussed is RUNX3; the disease is colorectal carcinoma.