CDKN2A and malignant colon neoplasm: In the same year, Slattery et al. [69] failed to find any significant association between self-reported PA and the methylation levels of five CpG island markers (amyloid beta precursor protein-binding family A member 1, MINT1; amyloid beta precursor protein-binding family A member 2, MINT2; amyloid beta precursor protein-binding family A member 31, MINT31; cyclin-dependent kinase inhibitor 2A, p16INK4A; human mutL homolog 1, hMLH1) in 1154 patients with colon cancer.