CACNA2D3 and cancer: These authors found that the methylation of CACNA2D3, correlated to gastric cancer [70], was higher in the sedentary carcinoma patients (45.5% of patients) than in those with at least 1 h of exercise per week before cancer onset (23.7% of patients) making this the first positive and specific epigenetic study related to the impact of PA on tumorigenesis.