They also found that a 6-month exercise intervention (3 h per week: 1 session of 1 h spinning and 2 sessions of 1 h aerobic) decreased DNA methylation of eight T2D candidate genes (runt related transcription factor 1, RUNX1; myocyte enhancer factor 2A, MEF2A; THADA armadillo repeat containing, THADA; NADH:ubiquinone oxidoreductase subunit C2, NDUFC2; adiponectin receptor 1, ADIPOR1; adiponectin receptor 2, ADIPOR2; bradykinin receptor B2, BDKRB2; RNA binding motif single stranded interacting protein 1, RBMS1). Here, ADIPOR2 is linked to type 2 diabetes mellitus.