In contrast, Yuasa et al. [64] studied tumors from 106 patients with gastric cancer and investigated the association between PA level, evaluated by self-administrated questionnaire, and the methylation status of several cancer-related genes, such as the homeobox transcription factor (CDX2), the bone morphogenetic protein 2 (BMP2), the GATA binding protein 5 (GATA5), the p16, the calcium voltage-gated channel auxiliary subunit alpha2delta 3 (CACNA2D3) and the estrogen receptor (ER). This evidence concerns the gene ESR1 and cancer.