Following results were obtained: (1) XPC A499 V was associated with increased risk of HNSCC, especially laryngeal carcinoma; (2) XPD K751Q was correlated with higher risk of oral SCC among women; (3) wild-type individuals of XRCC3 T241M exhibited an earlier age of onset; (4) XRCC1 R399Q homozygous mutant genotype determined HPV positivity. This evidence concerns the gene XRCC1 and head and neck squamous cell carcinoma.