TIMP3 and cervical carcinoma: With the discovery that global DNA hypomethylation progressively increases in cervical dysplasia and carcinoma [84], Widschwendter et al. [85] investigated DNA methylation in cervical vaginal specimens collected on a tampon of 11 host genes known to be methylated in cervical cancer (SOCS1, CDH1, TIMP3, GSTP1, DAPK, hTERT, CDH13, HSPA2, MLH1, RASSF1A, and SOCS2) and reported a correlation of the methylation status with the severity of the cervical lesion, such that invasive cervical cancers could be predicted.