JAG1 and adenoma: Interestingly, 4 out of 8 KrasLSL-G12D/+;Jag1flox/flox ;Pdx1-Cre (KJC) mice between 4 and 6 months of age showed near normal histology of the gallbladder, suggesting that deletion of Jag1 partially suppresses KrasG12D-induced adenoma development (Figure 2E).