Our current study also found that only 15.2% IHC-tested breast cancer biopsies at MNH showed HER2 expression while the rest were negative for this protein (Table 9, Fig. 2 (f&g)) and although this was not statistically significant (P-value = 0.213), we found that out of 22 biopsies positive for estrogen receptors, only 4.5% were also positive for human epidermal growth factor receptors type-2 while the rest were negative including 76% which were negative for both HER2 and ER (Table 10). Here, ESR1 is linked to breast cancer.