IFNA1 and Hepatic fibrosis: The majority of patients do not obtain Sustained Virologic Response.3,4 Previous studies indicated that IFN mediated response is correlated to several host factors such as age, ethnicity, transmission of blood and blood borne products, duration of infection, iron deposition and liver fibrosis.5 Some other studies suggest that IFN mediated response is related to HCV factors such as genotype6,7 viral load8 and quasispecies.9 An HCV nonstructural protein 5A quasispecies pattern has been extensively associated with interferon resistance.10