LAMB2 and Hepatic fibrosis: However, liver biopsy has many short comings.2 In recent years, some studies have proposed non-invasive, serum-based biomarkers: HA, laminin (LN), collagen IV (C-IV) and amino-terminal pro-peptide of Type-III pro-collagen (PIIINP) as indices of the extent of liver fibrosis in chronic liver diseases.3