It has been documented by various resent studies that the adipose tissue is not just a fat deposit but it also acts as an endocrine tissue and produces numerous hormone like proteins called adipokines including: leptin, adiponectin, vaspin, TNFa, IL 6, IL 10, resistin, visfatin and omentin.13 Visceral adipose tissue is dynamically involve in inflammation and its hypertrophy is associated with pathogenesis of various disorders like diabetes, metabolic syndrome, arthritis and CAD.14 Omentin-1 is newly identified protein secreted by omental visceral fat. The gene discussed is TNF; the disease is Arthritis.